Comportamiento electroquímico de nitrocompuestossíntesis y reducción electroquímica de 4-nitroimidazoles sustituidos y su comparación con 2- y 5-nitroimidazoles

Resumo

Nitroimizadoles have been the source of many investigations because of their properties as antibiotics, radiosensitizers and antiprotozoans. The pharmacological mechanism of action of these compounds is strongly connected with the reduction of them, mainly the one-electron reduction to form the nitro radical anion. Consequently the electrochemistry of these compounds plays an important role in its mechanism of action. In the present theses we have carried out comprehensive studies about a series of nitroimizadole derivatives in order to characterize its electrochemical behaviour in different media. For this purpose we have studied the electrochemical behaviour of some synthesized 4-nitroimizadole derivatives such as: 1-methyl-2-hydroxymethyl-4-nitroimizadol; 1-methyl-4-nitroimizadol-2-carboxyaldehyde; 1-methyl-4-nitroimizadol-2-carboxylic acid; 2-hidroximetil-4-nitroimizadol; 4-nitroimizadol-2-carboxyaldehyde and compared with other 2-and 5-nitroimizadol derivatives. The electrochemical study was carried out using mainly Cyclic Voltammetry but also other electrochemical techniques such as Tast and Diferential Pulse Polarography, Linear Sweep Voltammetry, controlled potential electrolysis and coulommetry were used.