Efectos del consumo de café para la salud cardiovascular, la diabetes y el desarrollo del cáncer
- Blanco Coronado, José Luis
- Moreno San Pedro, Emilio
- Gil Roales-Nieto, Jesús
- Gil Luciano, Ana
ISSN: 0214-9915
Année de publication: 2004
Volumen: 16
Número: 4
Pages: 531-547
Type: Article
D'autres publications dans: Psicothema
Résumé
Effects of coffee consume on cardiovascular health, diabetes and cancer. This paper presents a revision of the relationships between coffee consumption and health across the three groups of diseases that are the first causes of premature death: cardiovascular diseases, diabetes and cancer. Epidemiological and experimental studies show relative evidences of increasing cardiovascular risk correlated to coffee consumption while no clear relationship is found concerning diabetes. Relationships between coffee consumption and cancer risk are likely in the case of pancreas and ovarian cancers while coffee consumption appears as a protector factor in colorectal cancer with no concluding data in the case of bladder cancer. This paper also presents the available hypotheses concerning the mechanisms that might be responsible of coffee consumption as a risk or protector factor for the diseases revised, and healthy forms of coffee consumption that minimize risk are indicated
Références bibliographiques
- Abu-Zeid, H., Choi, N. y Hsu, P. (1981). Factors associated with risk of cancer of the colon and rectum. American Journal of Epidemiology, 114, 442-443.
- Ahola, I., Jauhiainen, M. y Aro, A. (1991). The hypercholesterolemic factor in boiled coffee is retained by a paper filter. Journal of Internal Medicine, 230, 293-297.
- American Institute for Cancer Research. (1997). World Cancer Research Fund and American Institute for Cancer Research. Food, Nutrition and the Prevention of Cancer: A Global perspective. En AIFCR (Ed.), Pancreas. Washington, DC: AIFCR.
- Arion, W., Canfield, W., Ramos, F. et al. (1997). Chlorogenic acid and hydrosynitrobenzaldehyde: new inhibitors of hepatic glucose-6-phosphatase. Archives of Biochemistry and Biophysic, 399, 315-322.
- Aro, A., Teirila, J. y Gref, C.G. (1990). Dose-dependent effect on serum cholesterol and apoprotein B concentrations by consumption of boiled, non-filtered coffee. Atherosclerosis, 83, 257-261.
- Aro, A., Tuomilehto, J., Kostiainen, E., Uusitalo, U. y Pietinen, P. (1987). Boiled coffee increases serum low density lipoprotein concentration. Metabolism, 36, 1.027-1.030.
- Biaggioni, I. y Davis, S. (2002). Caffeine: A cause of insulin resistance? Diabetes Care, 25, 399-400.
- Bjelke, E. (1974). Colon cancer and blood-cholesterol. Lancet, 1, 1.116-1.117.
- Brown, C.A., Boltonsmith, C., Woodward, M. y Tunstallpedoe, H. (1993). Coffee and tea consumption and the prevalence of coronary heart-disease in men and women- Results from the Scottish Heart Health Study. Journal of Epidemiology and Comunity Health, 47, 171-175.
- Byers, T., Marshall, J., Graham, S., Mettlin, C. y Swanson, M. (1983). A case-control study of dietary and nondietary factors in ovarian cancer. Journal of the National Cancer Institute, 71, 681-686.
- Cavin, C., Bezencon, C., Guignard, G. y Schilter, B. (2003). Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems. Biochemical and Biophysical Research Communications, 306, 488-495.
- Christensen, B., Mosdol, A., Retterstol, L., Landaas, S. y Thelle, D. (2001). Abstention from filtred coffee reduce the concentrations of plasma homocysteine and serum cholesterol- a randomized controlled trial. American Journal of Nutrition, 74, 302-307.
- Christensen, L. y Murray, T. (1990). A review of the relationship between coffee consumption and coronary heart disease. Journal of Community Health, 15, 391-408.
- Chyou, P., Nomura, A. y Stemmermann, G. (1993). A prospective study of diet, smoking and lowe urinary tract cancer. Annals of Epidemiology, 3, 211-216.
- Clifford, M. (2000). Chlorogenic acid and other cinnamates-nature, occurence, dietary burden, absorption and metabolism. Journal of Science Food Agric, 80, 1.033-1.043.
- Corti, R., Binggeli, C., Sudano, I., Spieker, L., Hänseler, E., Ruschitzka, F., Chaplin, W., Lüscher, T. y Noll, G. (2002). Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content. Role of habitual versus nonhabitual drinking. Circulation, 106, 2.935-2.940.
- Cramer, D. y Welch, W. (1983). Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis. Journal of the National Cancer Institute, 71, 717-721.
- Cramer, D., Welch, W., Hutchison, G. y Willett, W. (1984). Dietary animal fat in relation to ovarian cancer risk. Obstetrics and Gynecology, 63, 833-838.
- Crist, G., Xu, B., LaNoue, K. y Lang, C. (1998). Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. FASEB Journal, 12, 1.301-1.308.
- D’Amicis, A., Scaccini, C., Tomassi, G., Anaclerio, M., Stornelli, R. y Bernini, A. (1996). Italian style brewed coffee: effect on serum cholesterol in young men. International Journal of Epidemiology, 25, 513-520.
- Dales, L., Friedman, G., Ury, H. et al. (1979). A case-control study of relationships of diet and other traits to colorectal cancer in American blacks. American Journal of Epidemiology, 109, 132-144.
- deRoos, B. y Katan, M.B. (1999). Possible mechanisms underlying the cholesterol-raising effect of the coffee diterpene cafestol. Current Opinion in Lipidology, 10, 41-45.
- deRoos, B., Vanderweg, G., Urgert, R., Vandebovenkamp, P., Charrier, A. y Katan, M. B. (1997). Levels of Cafestol, Kahweol, and related diterpenoids in wild-species of the coffee plant coffea. Journal of Agricultural and Food Chemistry, 45, 3.065-3.069.
- Donato, F., Boffetta, P., Fazioli, R., Aulenti, V., Gelatti, U. y Porru, S. (1997). Bladder cancer, tobacco smoking, coffee and alcohol drinking in Brescia, nothern Italy. European Journal of Epidemiology, 13, 795-800.
- Escohotado, A. (1989). Historia de las drogas. Vol. 1. Madrid: Alianza Editorial.
- Feinberg, L., Sandberg, H., De Castro, O. y Bellet, S. (1968). Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects. Metabolism, 17, 916-922.
- Forde, O.H., Knutsen, S.F., Arnesen, E. y Thelle, D.S. (1985). The Tromso Heart Study: Coffee consumption and serum lipid concentrations in men with hypercholesterolemia: A randomized intervention study. British Medical Journal, 290, 893-895.
- Franceschi, S. (1993). Coffee and myocardial infarction: review of epidemiological evidence. En S. Garattini (Ed.), Caffeine, Coffee, and Health (pp. 195-211). New York: Raven Press.
- Fried, R.E., Levine, D.M., Kwiterovich, P.O., Diamond, E.L., Wilder, L.B., Moy, T.F. y Pearson, T.A. (1992). The effect of filtered-coffee consumption on plasma lipid levels: Results of a randomized clinical trial. Journal of American Medicine Association, 267, 811-815.
- Gil Roales-Nieto, J. (1999). Manual de Psicología de la Salud. Volumen II. Comportamiento y salud/enfermedad. Granada: Ediciones Némesis.
- Gil Roales-Nieto, J. (2004). Psicología de la Salud. Aproximación histórica, conceptual y aplicaciones. Madrid: Ediciones Pirámide.
- Gil Roales-Nieto, J., López Ríos, F. y Moreno San Pedro, E. (2001). Evolución de las características del consumo de tabaco: un estudio transversal. International Journal of Psychology and Psychological Therapy, 1, 78-91.
- Gil Roales-Nieto, J., Moreno San Pedro, E. y Blanco Coronado, J. (2001). Niveles de colesterol y consumo de café: Cafefusión como forma de consumo que elimina los efectos hipercolesterolemiantes del café. Universidad de Almería. Informe de investigación no publicado.
- Giovannucci, E. (1998). Meta-analysis of coffee consumption and risk of colorectal cancer. American Journal of Epidemiology, 147, 1.043-1.052.
- Greenland, S. (1993). A meta-analysis of coffee, myocardial infarction, and coronary death. Epidemiology, 4, 366-374.
- Greer, F., Hudson, R., Ross, R. y Graham, T. (2001). Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes, 50, 2.349-2.354.
- Grobbee, D. E., Rimm, E. B., Giovanucci, E., Colditz, G., Stampfer, M. y Willett, W.C. (1990). Coffee, caffeine, and cardiovascular disease in men. New England Journal of Medicine, 323, 1.026-1.032.
- Gross, G., Jaccaud, E., y Huggett, A.C. (1997). Analysis of the content of the diterpenes Cafestol y Kahweol in coffee brews. Food and Chemical Toxicology, 35, 547-554.
- Grubben, M., Boers, G., Blom, H., Broekhuizen, R., de Jong, R., van Rijt, L., de Ruijter, E., Swinkels, D., Nagengast, F. y Katan, M. (2000). Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: A randomized trial. American Journal of Nutrition, 71, 480-484.
- Harnack, L., Anderson, K., Zheng, W., Folsom, A., Sellers, T. y Kushi, L. (1997). Smoking, alcohol, coffee, and tea intake and incidence of cancer of the exocrine pancreas: the Iowa Women’s Health Study. Cancer Epidemiology Biomarkers y Prevention, 6, 1.081-1.086.
- Hartge, P., Lesher, L., McGowan, L. y Hoover, R. (1982). Coffee and ovarian cancer. International Journal of Cancer, 30, 531-532.
- Hartley, T., Sung, B., Pincomb, G., Whitsett, T., Wilson, M. y Lovallo, W. (2000). Hypertension risk status and effect of caffeine on blood pressure. Hypertension, 36, 137-141.
- Hartman, T., Tangrea, J., Pictinin, P. et al. (1998). Tea and coffee consumption and risk of colon and rectal cancer in middle-aged Finnish men. Nutrition and Cancer. An International Journal, 31, 41-48.
- Heckers, H., Gobel, U. y Kleppel, U. (1994). End of the coffee mystery-Diterpene alcohols raise serum low-density-lipoprotein cholesterol and tryglyceride levels. Journal of Internal Medicine, 235, 192-193
- International Agency for Research on Cancer. (1991). IARC Monographs of the evaluation of carcinogenic risks to humans. Vol. 51. Coffee, tea, mate, methylxanthines and methylglyoxal. Lyon: IARC.
- International Agency for Research on Cancer (1997). Coffee, tea, mate, methylxanthines and methylglyoxal. Lyon: IARC.
- Isogawa, A., Noda, M., Takahashi, Y., Kadowaki, T. y Tsugane, S. (2003). Coffee consumption and risk of type 2 diabetes mellitus. Lancet, 361, 703-704.
- Jacobsen, B. (1987). Coffee, cholesterol, and colon cancer: is there a link? British Medical Journal, 294, 4-5.
- Jacobsen, B. y Heuch, I. (2000). Coffee K-ras mutations and pancreatis cancer: A heterogeneous aetiology or an artefact? Journal of Epidemiology and Community Health, 54, 654-655.
- James, J. (1997). Is habitual caffeine use a preventable cardiovascular risk factor? Lancet, 349, 279-281.
- Jankelson, O., Beaser, S., Howard, F. y Mayer, J. (1967). Effect of coffee on glucose tolerance and circulating insulin in men with maturity-onset diabetes. Lancet, 1, 527-529.
- Jansen, D.F., Nedeljkovic, S., Feskens, E.J., Ostojic, M.C., Grujic, M.Z., Bloemberg, B.P. y Kromhout, D. (1995). Coffee consumption, alcohol use, and cigarette smoking as determinants of serum total and HDL cholesterol in two serbian cohorts of the Seven Countries Study. Arteriosclerosis, Trombosis and Vascular Biology, 15, 1.793-1.797.
- Jee, S., He, J., Whelton, P., Suh, I. y Klag, M. (1999). The effect of chronic coffee drinking on blood pressure. A meta-analysis of controlled clinical trials. Hypertension, 33, 647-652.
- Johnston, K., Clifford, M. y Morgan, L. (2003). Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: Glycemic effects of chlorogenic acid and caffeine. American Journal of Clinical Nutrition, 78, 728-733.
- Keijzers, G., De Galan, B., Tack, C. y Smits, P. (2002). Caffeine can decreased insulin sensitivity in humans. Diabetes Care, 25, 364-369.
- Klag, M., Wang, N.Y., Meoni, L., Brancati, F., Cooper, L., Liang, K.Y., Young, J. y Ford, D. (2002). Coffee intake and risk of hypertension. The Johns Hopkins Precursors Study. Archives of Internal Medicine, 162, 657-662.
- Kleemola, P., Jousilahti, P., Pietinen, P., Vartiainen, E. y Tuomilehto, J. (2000). Coffee consumption and the risk of coronary heart disease and death. Archives on Internal Medicine, 160, 3.393-3.400.
- Knowler, W., Pettitt, D., Saad, M. y Bennett, P. (1990). Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metabolism Review, 6, 1-27.
- Kuper, H., Mucci, L. y Trichopoulos, D. (2000). Coffee, pancreatic cancer and the question of causation. Journal of Epidemiology and Community Health, 54(9), 650-651.
- Kuper, H., Titus-Ernstoff, L., Harlow, B. y Cramer, D. (2000). Population based study of coffee, alcohol and tobacco use and risk of ovarian cancer. International Journal of Cancer, 88, 313-318.
- La Vecchia, C., Liati, P., Decarli, A., Negri, E. y Franceschi, S. (1987). Coffee consumption and risk of pancreatic cancer. International Journal of Cancer, 40, 309-313.
- Lam, L., Sparnins, V. y Wattenberg, L. (1982). Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans than enhance glutathione S-transferase in the mouse. Cancer Research, 42, 1.193-1.198.
- Lancaster, T., Muir, J. y Silagy, C. (1994). The effects of coffee on serum lipids and blood presure in a UK population. Journal of the Royal Society of Medicine, 87, 506-507.
- LaVecchia, C., Franceschi, S., Decarli, A., Gentile, A., Liati, P., Regallo, M. y Tognoni, G. (1984). Coffee drinking and the risk of epithelial ovarian cancer. International Journal of Cancer, 33, 559-562.
- Lentini, A., Kleinman, H., Mattioli, P. et al. (1998). Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation. Melanoma Research, 8, 131-137.
- Lima, D. (1990). Coffee, a Medicinal Plant. New York: Vantage Press.
- Lin, Y., Tamakoshi, A., Kawamura, T., Kikuchi, S., Motohashi, Y., Kurosawa, M., Ohno, Y. y JACC Study Group. (2002). Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. International Journal of Cancer, 99, 742-746.
- Lipids Research Clinics Program. (1984). The lipids research clinics coronary primary prevention trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. Journal of American Medical Association, 251, 365-374.
- López Abente, G. y Escolar, A. (2001). Tobacco consumption and bladder cancer in non-coffee drinkers. Journal of Epidemiology and Community Health, 55, 68-70.
- Lundsberg, L. (1998). Caffeine consumption. En G. Spiller (Ed.), Caffeine (pp. 199-224). Boca Ratón, Ca.:CRC.
- MacMahon, B., Yen, S., Trichopoulos, D., Warren, K. y Nardi, G. (1981). Coffee and cancer of the pancreas. The New England Journal of Medicine, 304, 630-633.
- Mahmud, A. y Feely, J. (2001). Acute effect of caffeine on arterial stiffness and aortic pressure waveform. Hypertension, 38, 227-231.
- Marchioli, R., Di Mascio, R., Marfisi, R. M., Vitullo, F. y Tognoni, G. (1996). Coffee intake and death from coronary heart disease (letter). British Medical Journal, 312, 1.539.
- Masedo, A. y Esteve, M. (2002). On the affective nature of chronic pain. Psicothema, 14, 511-515.
- Meyer, K., Kushi, L., Jacobs, D., Slavin, J., Sellers, T. y Folsom, A. (2000). Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. American Journal of Clinical Nutrition, 71, 921-930.
- Michaud, D., Giovannucci, E., Willett, W., Colditz, G. y Fuchs, C. (2001). Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States Cohorts. Cancer, Epidemiology, Biomarkers y Prevention, 10, 429-437.
- Miller, D., Rosenberg, L., Kaufman, D., Helmrich, S., Schottenfeld, D., Lewis, J., Stolley, P., Rosenshlin, N. y Shapiro, S. (1987). Epithelial ovarian cancer and coffee drinking. International Journal of Epidemiology, 16, 13-17.
- Miller, E., Formby, W., Rivera-Hidalgo, F. y Wright, J. (1988). Inhibition of hamster bucal pouch carcinogenesis by green coffee beans. Oral Surgery, 65, 745-749.
- Miyake, Y., Kono, S., Nishiwaki, M., Hamada, H., Nishikawa, H., Koga, H. y Ogawa, S. (1999). Relationship of coffee consumption with serum lipids and lipoproteins in japanese men. Annals of Epidemiology, 9(2), 121-126.
- Momas, I., Daures, J., Festy, B., Bontoux, J. y Gremy, F. (1994). Relative importance of risks factors in bladder carcinogenesis: Some new results about mediterranean habits. Cancer Cause and Control, 5, 326-332.
- Moreno San Pedro, E. y Gil Roales-Nieto, J. (2003). El modelo de creen- cias de salud: revisión teórica, consideración crítica y propuesta alternativa I: hacia un análisis funcional de las creencias en salud. International Journal of Psychology and Psychological Therapy, 3, 91-109.
- Myers, M. y Basinski, A. (1992). Coffee and coronary heart disease. Archives on Internal Medicine, 152, 1.767-1.772.
- Naismith, D., Akinyanju, P., Szanto, S. y Yudkin, J. (1970). The effect in volunteers of coffee and decaffeinated coffee on blood clotting. Nutrition and Metabolism, 12, 144-151.
- NAS (1982). Committee on diet, nutrition and cancer ‘Diet, nutrition and cancer’ National Research Council. Washington, DC: National Academy Press.
- Newby, D., Neilson, J., Jarvie, D. y Boon, N. (1996). Caffeine restriction has no role in the management of patients with symptomatic idiopathic ventricular premature beats. Heart, 76(4), 355-357.
- Nieto, F., Comstock, G., Chambless, L. y Malinow, R. (1997). Coffee consumption and plasma homocyst(e)ine: results from the atheroesclerosis risk in communities study. American Journal of Nutrition, 66, 1.475-1.477.
- Nomura, A., Heilbrun, L. y Stemmermann, G. (1986). Prospective study of coffee consumption and the risk of cancer. Journal of the National Cancer Institute, 76, 587-590.
- Nurminen, M., Niittynen, L., Korpela, R. y Vapaatalo, H. (1999). Coffee, caffeine and blood pressure: a critical review. European Journal of Clinical Nutrition, 53, 831-839.
- Nygard, O., Refsum, H., Ueland, P., Stensvold, I., Nordrehaug, J., Kvale, G. y Vollset, S. (1997). Coffee consumption and plasma total homocysteine. The Hordaland Homocysteine Study. American Journal of Nutrition, 65, 136-143.
- Olthof, M., Hollman, P., Zock, P. y Katan, M. (2001). Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. American Journal of Clinical Nutrition, 73, 532-538.
- Oshaug, A., Bugge, K. y Refsum, H. (1998). Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea. European Journal of Clinical Nutrition, 52, 7-11.
- Partanen, T., Hemminki, K., Vainio, H. y Kauppinen, T. (1995). Coffee consumption not associated with risk of pancreas cancer in Finlad. Preventive Medicine, 24, 213-216.
- Paul, O., Lepper, M.H., Phelan, W.H., Dupertuis, G.W., Macmillan, A. et al. (1963). A longitudinal study of coronary heart disease. Circulation, 28, 20-31.
- Pellicer, O., Salvador, A. y Benet, I. (2002). Efectos de un estresor académico sobre las respuestas psicológica e inmune en jóvenes. Psicothema, 14, 317-322.
- Phillips, R. y Snowdon, D. (1985). Dietary relationships with fatal colorectal cancer among Seventh-day Adventists. Journal of the National Cancer Institute, 34, 307-317.
- Pietinen, P., Geboers, J. y Kesteloot, H. (1988). Coffee consumption and serum cholesterol: An epidemiological study in Belgium. International Journal of Epidemiology, 17, 98-104.
- Pirich, C., Ogrady, J. y Sinzinger, H. (1993). Coffee, Lipoproteins and cardiovascular-disease. Wiener Klinische Wochenschrift, 105, 3-6.
- Pizziol, A., Tikhonoff, V., Paleari, C., Russo, E., Mazza, A., Ginocchio, G., Onesto, C., Pavan, L., Casiglia, E. y Pessina, A. (1998). Effects of caffeine on glucose tolerance: a placebo-controlled study. European Journal of Clinical Nutrition, 52, 846-849.
- Polychronopoulou, A., Tzonou, A., Hsieil, C., Kaprinis, G., Rebelakos, A., Toupadaki, N. y Trichopoulos, D. (1993). Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer. International Journal of Cancer, 55, 402-407.
- Porta, M., Malats, N., Alguacil, J., Ruíz, L., Jariod, M., Carrato, A., Rifà, J. y Guarner, L. (2000). Coffee, pancreatic cancer, and K-ras mutations: updating the research agenda. Journal of Epidemiology and Community Health, 54, 656-659.
- Porta, M., Malats, N., Guarner, L., Carrato, A., Rifà, J., Salas, A., Corominas, J., Andreu, M., Real, F. y PANKRAS II Study Group. (1999). Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. Journal of Epidemiology and Community Health, 53, 702-709.
- Pujolar, A., González, C., López Abente, G., Errezola, M., Izarzugaza, I., Nebot, M. y Riboli, E. (1993). Bladder cancer and coffee consumption in smokers and non-smokers in Spain. International Journal of Epidemiology, 22, 38-44.
- Rachima-Maoz, C., Peleg, E. y Rosenthal, T. (1998). The effect of caffeine on ambulatory blood pressure in hypertensive patients. American Journal of Hypertension, 11, 1.426-1.432.
- Rakic, V., Burke, V. y Beilin, L.J. (1999). Effects of coffee on ambulatory blood pressure in older men and women. Hypertension, 33, 869-873.
- Rebollo Arévalo, A. (2001). Estructura del Consumo en España. Madrid: Instituto Nacional del Consumo.
- Refsum, H., Ueland, P., Nygard, O. y Vollset, S. (1998). Homocysteine and cardiovascular disease. Annual Review of Medicine, 49, 31-62.
- Reunanen, A., Heliövaara, M. y Kimmo, A. (2003). Coffee consumption and risk of type 2 diabetes mellitus. Lancet, 361, 702-703.
- Rosenberg, L., Slone, D., Shapiro, S., Kaufman, D.W., Stolley, P.D. y Miettinen, O.S. (1980). Coffee drinking and myocardial infarction in young women. American Journal of Epidemiology, 111, 675-681.
- Ruiz del Castillo, M., Herráiz, M. y Blanch, G. (1999). Rapid analysis of cholesterol-elevating compounds in coffee brews by off-line high perfomance liquid chromatography/high resolution gas chromatography. Journal of Agricultural and Food Chemistry, 47, 1.525-1.529.
- Ruiz Lapuente, M., Armadans Gil, L., Vaqué Rafart, J., Rosselló Urgell, J., Albertí Jaume, J. y Chacón Castro, P. (1995). Relación entre el café y el colesterol plasmático en una población laboral femenina. Medicina Clínica, 105, 687-690.
- Salazar Martínez, E., Willett, W., Ascherio, A., Manson, J., Leitzmann, M., Stampfer, M. y Hu, F. (2004). Coffee consumption and risk for type 2 diabetes mellitus. Annals of Internal Medicine, 140(1), 1-8.
- Salmerón, J., Manson, J., Stampfer, M., Colditz, G., Wing, A. y Willett, W. (1997). Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. Journal of the American Medical Association, 277, 472-477.
- Sanguigni, V., Gallu, M., Ruffini, M.P. y Strano, A. (1995). Effects of coffee on serum cholesterol and lipoproteins: the Italian brewing method. Italian Group for the Study of Atherosclerosis and Dismetabolic Diseases, Rome II Center. European Journal of Epidemiology, 11(1), 75-78.
- Shearer, J., Farah, A., de Paulis, T., Bracy, D., Pencek, R., Graham, T. y Wasserman, D. (2003). Quinides of roasted coffee enhance action in conscious rats. Journal of Nutrition, 133, 3.529-3.532.
- Shi, C. (1997). Effects of caffeine and acetylcholine on glucose-stimulated insulin release from islet transplants in mice. Cellular Transplant, 6, 33-37.
- Shirlow, M. J. y Mathers, C.D. (1984). Caffeine consumption and serum cholesterol levels. International Journal of Epidemiology, 13, 422-427.
- Slattery, M., Caan, B., Anderson, K. y Potter, J. (1999). Intake of fluids and methylxantine-containing beverages: association with colon cancer. International Journal of Cancer, 81, 199-204.
- Slattery, M., West, D., Robinson, L. et al. (1990). Tobacco, alcohol, coffee, and caffeine as risk factors for colon cancer in a low-risk population. Epidemiology, 1, 141-145.
- Snowdon, D. y Phillips, R. (1984). Coffee consumption and risk of fatal cancers. American Journal of Public Health, 74, 820-823.
- Somoza, V., Lindenmeier, M., Wenzel, E., Frank, O., Erbersdobler, H. y Hofmann, T. (2003). Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques. Journal of Agricultural and Food Chemistry, 51, 6.861-6.869.
- Spiller, M. (1998). The chemical components of coffee. En G. Spiller (Ed.), Caffeine (pp. 97-161). Boca Raton, Ca.: CRC Press.
- Spriet, L., McLean, D., Dick, D., Hultman, E., Caderblad, G. y Graham, T. (1992). Caffeine ingestion and muscle metabolism during prolonged exercise in humans. American Journal of Physiology, 262, 891-898.
- Stensvold, I. y Jacobsen, B. (1994). A prospective study of 43,000 Norwegian men and women. Cancer Cause and Control, 5, 401-408.
- Stensvold, I., Tverdal, A. y Jacobsen, B.K. (1996). Cohort study of coffee intake and death from coronary heart disease over 12 years. British Medical Journal, 312, 544-545.
- Stolzenberg-Solomon, R., Miller, E., Maguire, M., Selhub, J. y Appel, L. (1999). Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population. American Journal of Clinical Nutrition, 69, 467-475.
- Superko, H.R., Bortz, W.J., Williams, P.T., Albers, J.J. y Wood, P.D. (1991). Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: A controlled, randomized trial. American Journal of Clinical Nutrition, 54, 599-605.
- Tavani, A., Pregnolato, A., La Vecchia, C., Negri, E., Talamini, R. y Franceschi, S. (1997). Coffee and tea intake and risk of cancers of the colon and rectum: a study of 3,530 cases and 7,057 controls. International Journal of Cancer, 73, 193-197.
- Terry, P., Bergkvist, L., Holmberg, L. y Wolk, A. (2001). Coffee consumption and risk of colorectal cancer in a population based prospective cohort of Swedish women. Gut, 49, 87-90.
- Thompson, W.G. (1994). Coffee: Brew of Bane? The American Journal of the Medical Sciences, 308, 49-57.
- Thong, F., Derave, W., Kiens, B., Graham, T., Urso, B. Wojtaszewski, J., Hansen, B. y Richter, E. (2002). Caffeine-induced impairment of insulin action but not insulin signalig in human skeletal muscle is reduced by exercise. Diabetes, 51, 583-590.
- Trichopoulos, D., Papapostolou, M. y Polychronopoulou, A. (1993). Coffee and ovarian cancer. International Journal of Cancer, 28, 691-693.
- Tuomilehto, J., Tanskanen, A., Pietinen, P. et al. (1987). Coffee consumption is corrrelated with serum cholesterol in middle-aged Finnish men and women. J. Epidemiol. Commun. Health, 41, 237-242.
- Tzonou, A., Day, N., Trichopoulos, D., Walker, A., Saliaraki, M., Papapostolou, M. y Polychronopoulou, A. (1984). The epidemiology of ovarian cancer in Greece: a case-control study. European Journal of Cancer and Clinical Oncology, 20, 1.045-1.052.
- Urgert, R., Essed, N., van der Weg, G., Kosmeijer-Schuil, T.G. y Katan, M.B. (1997). Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases. American Journal of Clinical Nutrition, 65, 519-524.
- Urgert, R. y Katan, M.B. (1997). The cholesterol-raising factor from coffee beans. Annual Review of Nutrition, 17, 305-324.
- Urgert, R., Kosmeijer-Schuil, T.G. y Katan, M.B. (1996). Intake levels, sites of action and excretion routes of the cholesterol-elevating diterpenes from coffee beans in humans. Biochemic. Soc. Transact., 24, 800-806.
- Urgert, R., Meyboom, S., Kuilman, M., Rexwinkel, H., Vissers, M.N., Klerk, M. y Katan, M.B. (1996). Comparison of effect of cafetière and filtered coffee on serum concentrations of liver aminotransferases and lipids: six month randomised controlled trial. British Medical Journal, 313, 1.362-1.366.
- Urgert, R., Schulz, A. y Katan, M. (1995). Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans. American Journal of Clinica Nutrition, 61, 149-154.
- Urgert, R., van Vliet, T., Zock, P. y Katan, M. (2000). Heavy coffee consumption and plasma homocysteine: A randomized control trial in healthy volunteers. American Journal of Nutrition, 72, 1.107-1.110.
- Urgert, R., Vanderweg, G., Kosmeijerschuil, T.G., Vandebovenkamp, P., Hovenier, R. y Katan, M.B. (1995). Levels of the cholesterol-elevating diterpenes Cafestol and Kahweol in varius coffee brews. Journal of agricultural and food chemistry, 43(8), 2.167-2.172.
- Urgert, R., Weusten-van der Wouw, M., Hovenier, R., Meyboom, S., Beynen, A. y Katan, M. (1997). Diterpenes from coffee beans decrease serum levels of lipoprotein(a) in humans: results from four randomised controlled trials. European Journal of Clinical Nutrition, 51, 431-436.
- van Dam, R. y Feskens, E. (2002). Coffee consumption and risk of type 2 diabetes mellitus. Lancet, 360, 1.477-1.478.
- van Rooij, J., Vanderstegen, G.H.D., Schoemaker, R.C., Kroon, C., Burggraaf, J., Hollaar, L., Vroon, T.F.F.P., Smelt, A.H.M. y Cohen, A.F. (1995). A placebo-controlled parallel study of the effect of two types of coffee oil on serum-lipids and transaminases. Identification of chemical-substances involved in the cholesterol-raising effect of coffee. American Journal of Clinical Nutrition, 61(6), 1.277-1.283.
- Vena, J., Freudenheim, J., Graham, S., Marshall, J., Zielezny, M., Swanson, M. y Sufrin, G. (1993). Coffee, cigarette smoking and bladder cancer in Western New York. Annals of Epidemiology, 3, 586-591.
- Verhoef, P., Pasman, W., van Vliet, T., Urgert, R. y Katan, M. (2002). Contribution of coffeine to the homocysteine-raising effect of coffee: A randomized controlled trial in humans. American Journal of Nutrition, 76, 1.244-1.248.
- Vineis, P. (1999). ras Mutations and a cup of coffee: cause, confounder, effect modifier, or what else? Journal of Epidemiology and Community Health, 53, 685.
- Viscoli, C., Lachs, M. y Horwitz, R. (1993). Bladder cancer and coffee drinking: a summary of case-control research. The Lancet, 341, 1.432- 1.437.
- Vlachopoulos, C., Kosmopoulou, F., Sofianidou, A., Stefanadis, C., O’Rourke, M., Stamatelopoulos, S. y Toutouzas, P. (2003). Smoking while drinking coffee: A harmful, synergistic effect on arterial stiffness. American Journal of Heart, 16, 148A.
- Wachmann, A., Hattner, R., George, B. y Bernstein, D. (1970). Effects of decaffeinated and nondecaffeinated coffee ingestion on blood glucose and plasma radioimmunoreactive insulin responses to rapid intravenous infusion of glucose in normal man. Metabolism, 19, 539-546.
- Wakabayashi, K., Kono, S., Shinchi, K., Honjo, S., Todoroki, I., Sakurai, Y., Umeda, T., Imanishi, K. y Yoshizawa, N. (1998). Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. European Journal of Epidemiology, 14, 669-673.
- Wei, M., Macera, C.A., Hornung, C.A. y Blair, S.N. (1995). The impact of changes in coffee consumption on serum cholesterol. Journal of Clinical Epidemiology, 48(10), 1.189-1.196.
- Weusten-Van der Wouw, M., Katan, M., Viani, R., Huggett, A., Liardon, R., Lund-Larsen, P., Thelle, D., Ahola, I., Aro, A., Meyboom, S. y Beynen, A. (1994). Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes. Journal of Lipid Research, 35, 721-733.
- Whelton, P.K. (1994). Epidemiology of hypertension. Lancet, 344, 101- 106.
- Wittemore, A., Wu, M., Paffenbarger, R., Sarles, D., Kampert, J., Grosser, S., Jung, D., Ballon, S. y Hendrickson, M. (1988). Personal and environmental characteristics related to epithelial ovarian cancer. II. Exposure to talcum powder, tobacco, alcohol, and coffee. American Journal of Epidemiology, 128, 1.228-1.240.
- Zeegers, M., Dorant, E., Goldbohm, R. y van der Brandt, P. (2001). Are coffee, tea, and total fluid consumption associated with bladder cancer risk? Results from the Netherlands Cohort Study. Cancer Causes and Control, 12, 231-238.
- Zeegers, M., Tan, F., Goldbohm, R. y van der Brandt, P. (2001). Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis. International Journal of Epidemiology, 30, 353-362.