Diversos metales pueden ser biomarcadores precoces de cáncer de pulmón
- A. Pereira-Vega 1
- B. Callejón-Leblic 2
- L.A. Padrón Fraysse 1
- S. García Garrido
- B.E. Urízar Catalán 1
- V.M. Ignacio Barrios 1
- L. Marín Barrera 1
- J.L. Gómez Ariza 2
- T. García Barrera 2
- 1 Servicio de Neumología y Alergia, Hospital Universitario Juan Ramón Jiménez
- 2 Departamento de Química, Universidad de Huelva
ISSN: 1889-7347
Any de publicació: 2020
Volum: 32
Número: 2
Pàgines: 106-117
Tipus: Article
Altres publicacions en: Revista española de patología torácica
Resum
Abstract: Background and objectives: Lung cancer (LC) has the highest mortality rate, especially due to its late diagnosis, with a lower chance of recovery. At the start of the carcinogenic process, before a clinical diagnosis, trace elements (metals or metalloids) play an important role by activating or inhibiting enzymatic reactions and metalloproteins. The objective of our study is to analyze the utility of different metals as early biomarkers (BM) for LC which are obtained in serum, urine and bronchoalveolar lavage (BAL) samples. Material and methods: We analyzed the total concentrations, including fractions of high and low molecular weight, of 11 metals in serum, urine and BAL samples from patients with LC, healthy controls (HC) and patients with non-cancerous respiratory pathology (NCP) using an analysis technique based on inductively coupled plasma mass spectrometry (ICP-QQQ-MS). Results: We obtained a clear discrimination between groups for the three samples analyzed. We obtained overexpressed or reduced metals in LC that could be used as BM. The concentration of vanadium (V) and chromium (Cr) in serum is clearly higher in patients with LC. We have shown that several metals (V, Cr and copper) related to the altered metabolic processes in LC such as oxidative stress and homeostasis and/ or their connections could be good BM for LC. Conclusions: in the population studied, several metals and their connections and correlations were clearly differentiated in the patients with lung cancer compared to the HC and NCP groups and they appear to be good biomarkers for the early diagnosis of lung cancer.