Efectos de la vacunación frente a Paratuberculosis antes o después dela infección. Estudio experimental en la especie caprina
- Royo, M.
- Seco, J.
- Fuertes, M.
- Fernández, M.
- Sevilla, I. A.
- Arrazuria, R.
- Serrano, M.
- Castaño, P.
- Ferreras, M. C.
- Benavides, J.
- Elguezabal, N.
- Pérez, V.
- María Jesús Alcalde Aldea (coord.)
- Valentín Pérez Pérez (coord.)
- Raúl Bodas Rodríguez (coord.)
- Juan José Mateos Fernández (coord.)
- Manuel Sánchez Rodríguez (coord.)
Publisher: Sociedad Española de Ovinotecnia y Caprinotecnia SEOC
ISBN: 978-84-608-8680-8
Year of publication: 2016
Pages: 355-360
Congress: Sociedad Española de Ovinotecnia y Caprinotecnia (SEOC). Jornadas (41. 2016. Talavera de la Reina - Toledo)
Type: Conference paper
Abstract
Vaccination is the most efficient paratuberculosis control method. This studyis aimed to assess the efficacy of vaccination before and after infection, in agoat experimental model. A total of 35 1-2 month-old goat kids wereemployed. Eight of them were vaccinated 1 month before infection with the K-10 strain of M. avium paratuberculosis (Map). Some goat kids wereeuthanized at 150 days post-infection (dpi) for checking the infectionestablishment. Then, 5 goat kids, previously infected, were vaccinated at 180dpi. At 360 dpi all the animals were killed and histopathological studies,peripheral immune response evaluation and Map isolation from faeces andtissues were carried out. Vaccination lead to the production of high levels ofIFN-γ that were lower in animals vaccinated after infection (IV). A decrease inthe number and severity of the lesions was observed in kids vaccinatedbefore infection (VI). However, a great individual variation was seen in goatsfrom IV group, with some animals showed focal or no lesions while othershave diffuse and severe forms. Map isolation was only achieved from twoanimals, from groups IV and only infected, at 360 dpi. Vaccination againstparatuberculosis prior to infection would have a clear protective effect, whileits therapeutic effect, when immunization is performed after infection, wouldnot occur in all the animals that show a great individual variation in theirresponse.