Asociación de la deficiencia de cinc con factores inmunológicos y clínicos

  1. Florea, D. 1
  2. García-Ávila, M. 1
  3. Millán, E. 1
  4. Sáez, L. 1
  5. López-González, B. 1
  6. Molina, J. 1
  7. Quintero, B. 1
  8. Cabeza, C.
  9. Planells, E. 1
  1. 1 Universidad de Granada
    info
    Universidad de Granada

    Granada, España

    ROR https://ror.org/04njjy449

    Geographic location of the organization Universidad de Granada
Journal:
Ars pharmaceutica

ISSN: 2340-9894,  0004-2927

Year of publication: 2010

Volume: 51

Issue: 3

Pages: 711-722

Type: Article

DIALNET GOOGLE SCHOLAR HANDLE: https://hdl.handle.net/10481/26625

More publications in: Ars pharmaceutica

Sustainable development goals

Abstract

INTRODUCTION: Zinc is an essential element for the proper functioning of the body at all stages of life, both for cell synthesis, tissue repair and brain development to growth. Cofactor of numerous enzymes (lactate dehydrogenase, alkaline phosphatase, carbonic anhydrase, carboxypeptidase, SOD, etc.), being very important for the functioning of the prostate, development of reproductive organs for proper functioning of the retina, and is involved in the regeneration of rhodopsin. The immune system requires Zn and is necessary for maintaining the structural integrity of DNA and the synthesis of nucleic acids and proteins. OBJECTIVE: The objective is to study the nutritional status of zinc in a healthy population and establish relationship with other factors such as exercise, alcohol consumption, and other biochemical parameters such as GOT, ALP, CPK, ALSO immunoglobulin G, immunoglobulin A, alpha 1 antitrypsin, lactate dehydrogenase, rheumatoid factor. METHODS: The study was conducted in a group of people from 21 to 59 years, 56 men and 61 women. Inclusion criteria were based on the acceptance of subjects to participate in the study and that these subjects did not display any pathology that could affect their nutritional status. Zn was analyzed by Atomic Absorption Spectrometry (AAS) in blood cells and plasma samples mineralized by wet. We applied a food frequency questionnaire, and through software Nutriben (Mataix, and Garcia Diz, 2006) won the% RDA. It was accepted by the Ethics Committee and informed consent. The clinical parameters analyzed were determined on a computer Hitachi autoanalyzer using a colorimetric method. RESULTS: The recommended intake of Zn in the adult population is 7 to 15 mg/d. Our results show that Zn intake below 2 / 3 of the RDA in 56% of individuals studied. In plasma, Zn deficiency occurs in 17%. There was a significant positive correlation between Zn levels and alcohol consumption, levels of GOT, ALP, CPK, ASO, Immunogen, InmunoA and alpha-1-antitrypsin, and negative with exercise intensity, LDH and rheumatoid factor. CONCLUSION: According to the results, it is necessary to control both the intake and plasma and cellular levels of Zn for the population are deficient in this mineral that lead to the development of numerous diseases, as demonstrated by the association found with immunological and clinical parameters that affect enzymatic cell integrity

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